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Can Aspirin Prevent Skin Cancer?

November 7, 2005

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Researchers have already concluded that the common aspirin can be effective in reducing the risk of death from a heart attack. Now Australian researchers say the often-overlooked over-the-counter medication might actually help reduce the risk of developing skin cancer.

The study, at the Queensland Institute of Medical Research, says people who regularly take non-steroidal anti-inflammatory drugs, also known as NSAIDS, might gain increased protection against skin cancer and sunspots. The findings, presented in the Journal of the American Academy of Dermatology, were compiled after studying 1,600 subjects over a 15-year period.

Researcher David Whitman said aspirin appears to shut down an enzyme known as cyclo-oxygenase, which is a trigger for development of some skin cancers. The enzymes also serve as a means for cancer cells to stimulate cells in the blood.

For aspirin to be effective, the research says long-term, consistent use is required. Subjects would need to take at least two tablets a week for five years, according to the study.

Though promising, Whitman said it's too early to base any firm conclusions on it. The next step, he says, would be clinical trials.

More than one million people are diagnosed with skin cancer each year. The incidence of melanoma, the deadliest form of skin cancer, is rising faster than any other cancer, according to the Skin Cancer Foundation.

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