Complain about a product or service

Study: PSA Test Doesn't Improve Prostate Cancer Survival Rate

January 9, 2006

• Feds Approve Drug for Enlarged Prostate • New Prostate Cancer Treatment Shows Promise • Broccoli Reduces Prostate Cancer Risk, Study Finds • Celebrex-Lipitor Combo May Halt Prostate Cancer • Exercise May Speed Prostate Tumor Growth • Soy Compound May Halt Spread of Prostate Cancer • Obesity Linked to Higher Prostate Cancer Mortality • Red Wine May Fight Prostate Cancer • Enlarged Prostate Doesn't Mean Cancer • Hopkins Researchers Claim Better Blood Test for Prostate Cancer • Severe Form of Enlarged Prostate Disease Discovered • Tomato-Broccoli Combo Can Help Shrink Prostate Cancers • Weight Gain Increases Risk of Dying from Prostate Cancer • Smoking Linked to Complications in Prostate Cancer Treatment • Newer Approach Urged in Screening for Aggressive Prostate Cancer • Aspirin May Prevent or Delay Enlarged Prostate • Hopkins Researchers Find Better Blood Test for Prostate Cancer • Prostate Radiation May Cause Problems Later • New Test Detects Prostate Cancer Spread Earlier • Castration May Be Advised in Advanced Prostate Cancer • Radiation Therapy May Be Best for Younger Prostate Cancer Patients • Study Recommends More Prostate Biopsies • Delayed Surgery May Be OK for Some Prostate Cancer Patients • Study: PSA Test Doesn't Improve Prostate Cancer Survival Rate • Prostate Cancer Genes Identified • Annual Prostate Cancer Screening Test Appears to Save Lives • FDA Panel Rejects Prostate Cancer Pill • PSA Test Still Useful, Hopkins Study Finds • No "Normal" PSA Level: Study • New Prostate Cancer Test Shows Promise • Lifestyle and Diet May Stop or Reverse Prostate Cancer Progression

A screening test for prostate cancer that measures prostate-specific antigen (PSA) levels does not improve survival, researchers at the Veterans Affairs (VA) Connecticut Healthcare System and Yale School of Medicine report in the January 9 Archives of Internal Medicine.

Prostate cancer is the most common cancer affecting American men and ranks second in mortality. According to the study, screening tests almost always increase the detection of cancer, but among other requirements for improving survival, the tumors detected must be both fatal (if left untreated) yet curable.

PSA, a protein produced in the prostate, is found in the blood of healthy men. Prostate cancer often increases PSA levels in the blood, but a similar increase can be caused by benign enlargement of the prostate gland (prostatism) or prostate infections.

To test the impact of prostate cancer screening on survival, the researchers conducted a case-control review of the medical records of over 1,000 male veterans age 50 or older receiving care at 10 VA medical centers in New England.

Half of the men had died with prostate cancer; the other half were living and matched to be the same age as those who died. The study included up to nine years of follow-up after the diagnosis of cancer. The researchers compared the group that died with the group that lived and found that the same fraction of men had received screening with the PSA test.

"This study suggests that screening was not effective," said first author John Concato, M.D., associate professor of medicine at Yale School of Medicine and director of the Clinical Epidemiology Research Center at the VA Connecticut Healthcare System. "If screening worked, men who died would have had less testing than those who lived."

Concato and his team also determined that digital rectal examinations along with PSA did not improve survival.

"Unfortunately, screening tests can sometimes find cancer, even at early stages, but not prolong survival," said Concato, who is also a member of the Yale Cancer Center. "Rather than encouraging annual screening of all men starting at age 50, as is commonly done, the limited effectiveness of PSA testing should be explained to patients in the process of obtaining their informed consent to the test."

Report Your Experience
If you've had a bad experience -- or a good one -- with a consumer product or service, we'd like to hear about it. All complaints are reviewed by class action attorneys and are considered for publication on our site. Knowledge is power! Help spread the word. File your consumer report now.