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Gene Changes Identified in Alzheimer's

January 15, 2007

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Variations in a gene known as SORL1 may be a factor in the development of late-onset Alzheimer's disease, an international team of researchers has discovered.

The genetic clue, which could lead to a better understanding of one cause of Alzheimer's, is reported in Nature Genetics online, and was supported in part by the National Institutes of Health (NIH).

The researchers suggest that faulty versions of the SORL1 gene contribute to formation of amyloid plaques, a hallmark sign of Alzheimer's in the brains of people with the disease. They identified 29 variants that mark relatively short segments of DNA where disease-causing changes could lie.

The study did not, however, identify specific genetic changes that result in Alzheimer's.

Richard Mayeux, M.D., of Columbia University, Lindsay Farrer, Ph.D., of Boston University, and Peter St. George-Hyslop, M.D., of the University of Toronto, led the study, which involved 14 collaborating institutions in North America, Europe and Asia, and 6,000 individuals who donated blood for genetic typing.

"We do not fully understand what causes Alzheimer's disease, but we know that genetic factors can play a role," says National Institute on Aging (NIA) director Richard J. Hodes, M.D.

"Scientists have previously identified three genes, variants of which can cause early onset Alzheimer's, and one that increases risk for the late onset form. This discovery provides a completely new genetic clue about the late onset forms of this very complex disease. We are eager to investigate the role of this gene further."

Scientists think that in Alzheimer's disease, amyloid precursor protein, or APP, is processed into amyloid beta protein fragments that make up plaques in the brain. The researchers began their search for genetic influences amid a group of proteins that transport APP within cells, looking for small changes, or "misspellings," in seven genes involved in moving APP within cells.

"We are seeing the gene implicated in multiple data sets, across ethnic and racial groups," said Farrer. He adds that the group was "encouraged and excited" by cell biology experiments that demonstrate SORL1's role in production of beta amyloid fragments.

Examining blood cells from people with and without Alzheimer's, the researchers found less than half the level of SORL1 protein in people with Alzheimer's compared with people without the disease. In laboratory experiments, they found that altering the levels of SORL1 changed the way APP was moved around in cells, with low levels of SORL1 resulting in increased production of amyloid beta fragments while high levels decreased production.

However, the researchers note, other genetic and non-genetic factors are likely to affect SORL1 production in people, and more research is needed to determine the how different versions of the SORL1 gene influence production of the harmful protein fragments.

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