Complain about a product or service

Smoking Turns On Genes -- Permanently

Other genes, those involved in DNA repair, were switched off permanently

Augut 29, 2007

• Vermont Court Holds R.J. Reynolds Accountable for Misleading Ads • Study: 'Electronic Cigarettes' Need Evaluation, Regulation • Cold Turkey May Be Best Way To Quit Smoking • California Sues E-Cigarette Marketer • Study: Quit Smoking And Save Your Vision • Report: States Cut Funding for Tobacco Prevention Programs • Study: Herbal Cigarettes No Healthier Than Regular Smokes • Companies Warned Against Marketing Illegal Flavored Cigarettes • Study: Just One Cigarette Can Harm Young Healthy Adults • Smoking Bans Cut Heart Attack Risks Associated With Secondhand Smoke • FDA Bans Candy- and Fruit-Flavored Cigarettes • Heart Attack Rates Drop After Smoking Bans • Oregon Sues Electronic Cigarette Maker • Oregon Halts Sale Of Electronic Cigarettes • Experts Warn About Electronic Cigarettes • Turning The Tables On Big Tobacco • Senate Approves Bill For FDA Tobacco Regulation • Florida Smoker's Widow Awarded $30 Million • Court Finds Tobacco Companies Lied About Smoking Dangers • California Reinstates Tobacco Fraud Class Action --- • More about Smoking & Health

While smoking is no longer considered sexy, it may prove a permanent turn-on for some genes.

Research published in the online open access journal BMC Genomics could help explain why former smokers are still more susceptible to lung cancer than those who have never smoked.

A Canadian team led by Wan Lam and Stephen Lam from the BC Cancer Agency in British Columbia, Canada, took samples from the lungs of 24 current and former smokers, as well as from non-smokers who have never smoked. They used these lung samples to create libraries using a technique called serial analysis of gene expression (SAGE), which helps to identify patterns of gene activity.

Only about a fifth of the genes in a cell are switched on at any given time, but environmental changes such as smoking lead to changes in gene activity.

The researchers found changes that were irreversible, and some changes that were reversed by stopping smoking.

The reversible genes were particularly involved in xenobiotic functions (managing chemicals not produced in the body), nucleotide metabolism and mucus secretion. Some DNA repair genes are irreversibly damaged by smoking, and smoking also switched off genes that help combat lung cancer development.

The researchers identified a number of genes not previously associated with smoking that are switched on in active smokers. One example is CABYR, a gene involved in helping sperm to swim and associated with brain tumors, which may have a ciliary function.

"Those genes and functions which do not revert to normal levels upon smoking cessation may provide insight into why former smokers still maintain a risk of developing lung cancer," according to Raj Chari, first author of the study. The study is the largest human SAGE study reported to date, and also generated a large SAGE library for future research.

Tobacco smoking accounts for 85 percent of lung cancers, and former smokers account for half of those newly diagnosed with the disease.

Report Your Experience
If you've had a bad experience -- or a good one -- with a consumer product or service, we'd like to hear about it. All complaints are reviewed by class action attorneys and are considered for publication on our site. Knowledge is power! Help spread the word. File your consumer report now.

Follow us on Twitter.